In the 1920s Italian-speaking laity in Everett, Massachusetts appealed to William Cardina O'Connell for an Italian parish. O'Connell turned to a congregation of male religious then known as the Pious Society of Saint Charles, later the Society of Saint Charles-Scalabrinians, after their founder.
The congregation had been founded in 1887 to minister to migrants in transit and in their new homes, and had been working among Italians in Boston since 1888. O'Connell asked the congregation to staff the new parish in Everett, and the congregation sent Luigi Buggini from Sacred Heart in Boston to be the first pastor.
In 1927, the nascent parish rented Everett's Broadway Theatre, and Messrs. Pierotti and Accurzio Indelicato led the process of renovating it for a church. The first Mass took place on Palm Sunday, April 1, 1928.
In 1932, Saint Anthony's moved to a proper church and purchased 38 Oakes Street for a rectory.
In the late twentieth and early twenty-first centuries, the Scalabrini Fathers' service at Saint Anthony's expanded to include pastoral care of Spanish- and Portugese-speaking immigrants, as well as the English- speaking offspring of these and the earlier Italian immigrants.